Stanford Cancer Imaging Training (SCIT) Program

SCIT Program Seminars

The SCIT program hosts a quarterly colloquium during which two trainees present the status of their research.

NEXT SEMINAR:

Wednesday, September 23, 2015
12:00 PM
Glazer Learning Center (Lucas, P083)

Presenters:

"Automated Grading of Gliomas in Digital Pathology Images"
Mehmet Ertosun, PhD

Abstract: Coming soon


"Immune-Modulating Effects of the FDA Approved Iron Oxide Nanoparticle Ferumoxytol Inhibit Tumor Growth"
Saeid Zanganeh, PhD

Abstract: Ferumoxytol is an FDA-approved superparamagnetic iron oxide nanoparticle (USPIO) used for diagnostic in vivo imaging. Ferumoxytol is preferentially phagocytosed by tumor-associated macrophages (TAMs), and enables quantitative evaluation of initial tumor perfusion, tumor retention and persistent magnetic resonance-enhancement. Surprisingly, mammary adenocarcinoma-bearing mice injected with ferumoxytol had significantly smaller tumors at end-stage as compared to littermate controls injected with PBS. To determine mechanisms underlying ferumoxytol-induced tumor suppression, we examined the impact of ferumoxytol on macrophages and malignant tumor cells using in vitro and in vivo assays. Our data revealed no induced cytotoxicity to mammary adenocarcinoma cells incubated with either ferumoxytol or macrophages; however, when added in combination, carcinoma cells exhibited increased cleaved caspase-3 positivity.  Macrophages exposed to ferumoxytol in vitro exhibited altered gene expression programing wherein mRNAs associated with pro-inflammatory TH1-type responses were increased, e.g., TNFa, iNOS, CD68, and mRNAs associated with immune-suppression and TH2-type responses instead decreased, e.g., IL10, CD206.  In vivo, mammary adenocarcinoma growth was significantly suppressed in mice injected with intratumoral ferumoxytol, and correlated with increased presence of monocyte/macrophages exhibiting an immune-stimulatory or TH1-type phenotype as revealed by histopathology and FACS.



Previous Seminars




Optimization of a Fast CT System for More Accurate Radiotherapy
Erica Cherry, PhD
August 27, 2014

Iron Oxide Nanoparticles Inhibit Tumor Growth
Saeid Zanganeh, PhD
August 27, 2014


Image-guided Ultrasound Facilitated Drug Delivery Into Tumors In Vivo
Tzu-Yin Wang, PhD
May 7, 2014

Novel Radiation Detector Capable of Measuring the Energy of Individual X-ray Photons at High-Flux Rates to Advance X-ray Imaging Technologies for Cancer
Mehmet Gunhan Ertosun, PhD
May 7, 2014


Wide-Field Fluorescence Endoscopy and Dual-Axis Confocal Microscopy For Targeted Imaging of Cathepsin Activity in Colon Cancer
Steven Sensarn, PhD
February 5, 2014

Using High-Energy Electrons for Radiation Treatments and Cancer Imaging
Erica Cherry, PhD
February 5, 2014


Endoluminal Approaches to MRI-guided Ultrasonic Ablation of Tumors
Graham Sommer, MD
October 2, 2013

Image-guided Ultrasound Facilitated Drug Delivery Into Tumors: Optimization of Treatment Strategy Based on Quantitative Measurement of Cavitation
Tzu-Yin Wang, PhD
October 2, 2013


Making Sense of Optical Contrast for Point-of-Care Pathology
Steven Sensarn, PhD
June 19, 2013

Quantitative Analysis of Bone Tumors on Radiography: A Step Towards Diagnostic Imaging Based Analytics
Bhavya Shah, MD
June 19, 2013


T2-weighted Contrast in Breast MRI
Catherine Moran, PhD
March 22, 2013

3D MDCT Detection of Extrapancreatic Perineural Spread in Pancreatic Adenocarcinoma: A Radiologic Biomarker?
Bhavik Patel, MD
March 22, 2013



MRI-Based Biomarkers of Therapeutic Response in Triple-Negative Breast Cancer
Daniel Golden, PhD
December 12, 2012

Technical Development and Clinical Evaluation of Diffraction Enhanced Imaging for Breast Applications
Christopher Parham, MD, PhD
December 12, 2012


Fluorescence Imaging of Cancer Using Dual-axis Confocal Microscopy and Wide-field Endoscopy
Steven Sensarn, PhD
September 19, 2012

Sodium Fluoride PET/CT: An Advanced Imaging Technique to Identify and Predict The Behavior of Painful Osseous Metastases For Early Intervention
Bhavya Shah, MD
September 19, 2012


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Improving Radiation Therapy for Moving Tumors
Sarah Geneser, PhD
June 20, 2012

T2 Weighted Imaging for Improved Lesion Characterization in Breast MRI
Catherine Moran, PhD
June 20, 2012


MR Guided Focused Ultrasound Surgery
Pejman Ghanouni, MD, PhD
March 7, 2012

In Line MRI-linac Configuration
Dragos E. Constantin
March 7, 2012


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