Stanford Cancer Imaging Training (SCIT) Program

SCIT Program Seminars

The SCIT program hosts a quarterly colloquium during which two trainees present the status of their research.

NEXT SEMINAR:
Wednesday, August 27, 2014
10:00 am - 11:00 am

Glazer Learning Center (Lucas Center, Room P083)

 

"Optimization of a Fast CT System for More Accurate Radiotherapy"
Erica Cherry, PhD

Abstract: One of the greatest challenges in radiation therapy is delivering the treatment to the correct location in the body despite physiological motion.  A medical device is being developed to irradiate cancer more accurately using a high-energy electron beam that scans over the patient fast enough to essentially freeze this motion.  Accurate irradiation of the tumor requires fast imaging immediately prior to the treatment and rapid adaptation of the radiotherapy plan to the patient’s current position.  This lecture will focus on the process of designing a CT system that will be used to image cancer in as little time as possible while still providing reasonable image quality.  This involves optimization of the system geometry, image reconstruction method, artifact and scatter reduction techniques, and image registration method.

 

 

"Iron Oxide Nanoparticles Inhibit Tumor Growth"
Saeid Zanganeh, PhD

Abstract: Superparamagnetic iron oxide nanoparticles (SPIO) and ultrasmall SPIO (USPIO) have been used for cancer MR imaging for many years. While investigating the MR signal characteristics of USPIO in tumors, we recently discovered a surprising therapeutic effect: Tumor cells co-injected with USPIO showed a markedly inhibited growth rate compared to tumor cells only. The purpose of this project is to evaluate the underlying mechanisms that lead to these intrinsic therapeutic effects of USPIO. We will present results of in vitro studies, which evaluated potential direct toxic effects of USPIO on MMTV PyMT mammary carcinoma cells and indirect effects of USPIO on macrophage migration and polarization. In addition, we compared local iron content, microvessel density, macrophage quantity and immune cells polarizations of USPIO co-implanted tumors and control tumors in MMTV PYMT mice by serial MR imaging studies, optical imaging studies, histological analyses and FACS analyses. Our data indicate that iron oxide nanoparticles attract macrophages to early breast cancers, which leads to M1 innate immune responses and cytotoxic effects against cancer cells. These intrinsic immune modulatory effects of USPIO may be useful in conjunction with cancer immunotherapies and could be leveraged for the design of theranostic nanoparticles.

 

 



Previous Seminars

Image-guided Ultrasound Facilitated Drug Delivery Into Tumors In Vivo
Tzu-Yin Wang, PhD
May 7, 2014

Novel Radiation Detector Capable of Measuring the Energy of Individual X-ray Photons at High-Flux Rates to Advance X-ray Imaging Technologies for Cancer
Mehmet Gunhan Ertosun, PhD
May 7, 2014


Wide-Field Fluorescence Endoscopy and Dual-Axis Confocal Microscopy For Targeted Imaging of Cathepsin Activity in Colon Cancer
Steven Sensarn, PhD
February 5, 2014

Using High-Energy Electrons for Radiation Treatments and Cancer Imaging
Erica Cherry, PhD
February 5, 2014


Endoluminal Approaches to MRI-guided Ultrasonic Ablation of Tumors
Graham Sommer, MD
October 2, 2013

Image-guided Ultrasound Facilitated Drug Delivery Into Tumors: Optimization of Treatment Strategy Based on Quantitative Measurement of Cavitation
Tzu-Yin Wang, PhD
October 2, 2013


Making Sense of Optical Contrast for Point-of-Care Pathology
Steven Sensarn, PhD
June 19, 2013

Quantitative Analysis of Bone Tumors on Radiography: A Step Towards Diagnostic Imaging Based Analytics
Bhavya Shah, MD
June 19, 2013


T2-weighted Contrast in Breast MRI
Catherine Moran, PhD
March 22, 2013

3D MDCT Detection of Extrapancreatic Perineural Spread in Pancreatic Adenocarcinoma: A Radiologic Biomarker?
Bhavik Patel, MD
March 22, 2013



MRI-Based Biomarkers of Therapeutic Response in Triple-Negative Breast Cancer
Daniel Golden, PhD
December 12, 2012

Technical Development and Clinical Evaluation of Diffraction Enhanced Imaging for Breast Applications
Christopher Parham, MD, PhD
December 12, 2012


Fluorescence Imaging of Cancer Using Dual-axis Confocal Microscopy and Wide-field Endoscopy
Steven Sensarn, PhD
September 19, 2012

Sodium Fluoride PET/CT: An Advanced Imaging Technique to Identify and Predict The Behavior of Painful Osseous Metastases For Early Intervention
Bhavya Shah, MD
September 19, 2012


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Improving Radiation Therapy for Moving Tumors
Sarah Geneser, PhD
June 20, 2012

T2 Weighted Imaging for Improved Lesion Characterization in Breast MRI
Catherine Moran, PhD
June 20, 2012


MR Guided Focused Ultrasound Surgery
Pejman Ghanouni, MD, PhD
March 7, 2012

In Line MRI-linac Configuration
Dragos E. Constantin
March 7, 2012


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