Stanford Cancer Imaging Training (SCIT) Program

SCIT Program Seminars

The SCIT program hosts a quarterly colloquium during which two trainees present the status of their research.

NEXT SEMINAR:

Wednesday, June 10, 2015
10:00 am
Glazer Learning Center (Lucas, P083)

Presenters:

"Optimization of a Fast CT System for Motion Management in Electron Radiotherapy"
Erica Cherry, PhD

Abstract: One of the greatest challenges in radiation therapy is delivering treatment to the correct location in the body despite physiological motion.  A radiotherapy device is being developed to irradiate tumors more accurately using a high-energy electron beam that scans the patient fast enough to essentially freeze this motion.  There are several imaging challenges associated with this work, including acquiring an image of the patient on the day of treatment, registering that image to patient’s position at the time of treatment planning, and verifying that the patient has not moved while the treatment plan was adapted.  This talk will focus on the process and result of designing an optimized CT system that can perform all of these tasks but is not prohibitively expensive.

"Magnetogenetic Cancer Therapy"
Ryan Spitler, PhD

Abstract: The field of magnetic hyperthermia has shown tremendous promise, allowing for the specific heating of cells and tissues. This method uses magnetic materials such as superparamagnetic iron oxide nanoparticles (SPIONs) to selectively absorb energy from low frequency alternating magnetic fields relative to their surroundings, which is subsequently dissipated as heat. Maximum heating can be achieved by optimizing frequency and magnetic field strength in addition to optimizing SPIONs for magnetic absorption properties. We are developing a system in which magnetic nanoparticles and alternating magnetic fields will be used to achieve moderate temperature increases up to ~42°C for short periods of time, which will drive gene expression. In order to achieve more direct and flexible control of gene expression, we are using bacterial heat-shock elements, which readily respond to thermal stress as part of the naturally occurring response pathway. These heat-shock elements have been engineered to induce direct gene expression by bacterial cells conjugated to SPIONs and exposed to an external alternating magnetic field to achieve the target temperature rise ~5°C. The use of alternating magnetic fields for magnetothermal gene activation and to execute complex genetic programs within bacterial cells that confer a therapeutic effect on the mammalian host, defines a new field that we refer to as magnetogenetics.

By utilizing the natural and unique tumor-homing capabilities of bacteria we will combine this new technology with cancer therapy. Magnetic bacteria (bacteria that contain or are decorated with magnetic nanoparticles) will be tracked by MRI as well as form the basis for complex magnetothermal gene activation upon application of an alternating magnetic field. Using a synthetic biology approach, we will genetically engineer bacteria to secrete toxic and immune modulating factors such as cytokines at the tumor site, under magnetothermal control. This approach has several advantages over other cancer therapies; these include biological homing of the therapeutic vehicle to the tumor site, genetically driven local activation of therapeutic agents without having to know the exact location of the tumor site, reduction of off target effects since the bacteria will deliver their payload only when the tumor site is reached, and vaccination of the host at the tumor site, likely reducing the number of circulating tumor cells and suppressing tumor formation and growth everywhere in the body. This work represents the first magnetogenetic cancer treatment modality.

 



Previous Seminars



Optimization of a Fast CT System for More Accurate Radiotherapy
Erica Cherry, PhD
August 27, 2014

Iron Oxide Nanoparticles Inhibit Tumor Growth
Saeid Zanganeh, PhD
August 27, 2014


Image-guided Ultrasound Facilitated Drug Delivery Into Tumors In Vivo
Tzu-Yin Wang, PhD
May 7, 2014

Novel Radiation Detector Capable of Measuring the Energy of Individual X-ray Photons at High-Flux Rates to Advance X-ray Imaging Technologies for Cancer
Mehmet Gunhan Ertosun, PhD
May 7, 2014


Wide-Field Fluorescence Endoscopy and Dual-Axis Confocal Microscopy For Targeted Imaging of Cathepsin Activity in Colon Cancer
Steven Sensarn, PhD
February 5, 2014

Using High-Energy Electrons for Radiation Treatments and Cancer Imaging
Erica Cherry, PhD
February 5, 2014


Endoluminal Approaches to MRI-guided Ultrasonic Ablation of Tumors
Graham Sommer, MD
October 2, 2013

Image-guided Ultrasound Facilitated Drug Delivery Into Tumors: Optimization of Treatment Strategy Based on Quantitative Measurement of Cavitation
Tzu-Yin Wang, PhD
October 2, 2013


Making Sense of Optical Contrast for Point-of-Care Pathology
Steven Sensarn, PhD
June 19, 2013

Quantitative Analysis of Bone Tumors on Radiography: A Step Towards Diagnostic Imaging Based Analytics
Bhavya Shah, MD
June 19, 2013


T2-weighted Contrast in Breast MRI
Catherine Moran, PhD
March 22, 2013

3D MDCT Detection of Extrapancreatic Perineural Spread in Pancreatic Adenocarcinoma: A Radiologic Biomarker?
Bhavik Patel, MD
March 22, 2013



MRI-Based Biomarkers of Therapeutic Response in Triple-Negative Breast Cancer
Daniel Golden, PhD
December 12, 2012

Technical Development and Clinical Evaluation of Diffraction Enhanced Imaging for Breast Applications
Christopher Parham, MD, PhD
December 12, 2012


Fluorescence Imaging of Cancer Using Dual-axis Confocal Microscopy and Wide-field Endoscopy
Steven Sensarn, PhD
September 19, 2012

Sodium Fluoride PET/CT: An Advanced Imaging Technique to Identify and Predict The Behavior of Painful Osseous Metastases For Early Intervention
Bhavya Shah, MD
September 19, 2012


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Improving Radiation Therapy for Moving Tumors
Sarah Geneser, PhD
June 20, 2012

T2 Weighted Imaging for Improved Lesion Characterization in Breast MRI
Catherine Moran, PhD
June 20, 2012


MR Guided Focused Ultrasound Surgery
Pejman Ghanouni, MD, PhD
March 7, 2012

In Line MRI-linac Configuration
Dragos E. Constantin
March 7, 2012


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